Two very good interviews with Small Beer Press's Kelly Link & Gavin Grant have surfaced lately: one from 2010 on some of Kelly's writing methods that she's adopted from other writers (ask your subconscious for ideas, put in things you like from other stories, write a lot of first sentences and select the best), and the other from author Alma Katsu (endpaper notes) with both Grant and Kelly about how to run a small press ("odd-shaped books" that others won't publish, but that match your taste are a good bet [if you've got good taste].)
I really like the list of things to put in stories: "fraught family dynamics", "people who make things", "electrical outages". The fifty first lines idea reminds me of the pottery class described by Malcolm Gladwell where the professor grades by the number of pots made, rather than the quality, and ends up with better results.
I also think that Small Beer is one of the most interesting publishers in America, both from the standpoint of the many great books they've brought onto the market, but also in their overall business model as an indie publisher. They produce quite a lot for their size, seem to be profitable, and have a good reputation with both customers and authors.
More: I don't remember whether I have already posted this interview with Link called "All Books are Weird"from Weird Fiction Review.